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Cake day: June 23rd, 2023

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  • Building on this, I’d be curious to hear your thoughts on GrapheneOS as a whole. The OS recently bundled a new app “store”/repository, "Accrescent”, along with the usual basic apps like a calculator & camera. On Accrescent, the hardened fork of Signal, Molly, is offered on there. I’ve alsoheard one of the Graphene devs has voiced some chuddy politics.

    I’ve still installed & use Molly to chat with my closest friends who I was able to get off of big tech platforms previously used for our group chats, but I have been aware of the RFA/Signal connection for several years (your blog post really ties it together) & I do try to remind these friends about it. Really we just use Signal to shitpost and organize hangouts, so I’m not yet locking myself in a bunker over using it for those purposes, but all this has got me considering building a server & hosting a different secure chat service on it.

    I learned about possible Unit 8200 connections with the Matrix protocol within the past year or two, but don’t recall exactly what that entails. I haven’t heard much about Briar, but it being android only would make it a harder sell for getting people to switch over to it, so I suppose that leaves simpleX to proselytize.














  • Not to mention meeting standards of purity and formulating your medication so it’s shelf stable and the active pharm ingredient can be distributed within the body effectively once the medicine is administered.

    I’ve had similar thoughts as these jokers but with using bioreactors. Each time I conclude that the solution is a centralized manufacturing facility owned by workers to effectively produce at scale (and ensure you don’t poison people).

    Sure, you’re not gonna build that misoprostol plant in Texas, but there’s other options to obtain properly-manufactured medication before you drink a mystery brew cooked up by an anarchist squatter named Spoon.


  • Absolutely, and I don’t see biohackers offering up cheap NMR or MS/MS detectors to solve the common issue of inadvertently making side products like MPTP when attempting to cook up MPPP or whatever, consequently injecting Parkinson’s into yourself. So you’re still bound by the enormous costs of getting an analytical lab stood up, despite using “AI” assisted synthetic software to substitute for real verification of each purified intermediate product. Also my other chem friend & I think that Vinni guy is an annoying ted-talk dude fwiw.


  • Very cool that they’ve published a FOSS version of in-silico synthetic software plus designed a jacketed reactor (much more convenient than babysitting a round bottomed flask in a mantle for 12 hours), but I can’t see it getting to very high or even mildy low temps.

    I don’t see much about cleaning the reactor feedlines or reactant reservoirs, nor how you take a reaction product and work it up, or purify it for that matter, in preparation for the next synthetic step. Classico synthesis traditionally structurally elucidates each step’s purified product with NMR before carrying it forward to the next rxn. But I’m a lazy chemist so I’d prefer to program microbes to make things for me (: